Elliot Murphy, PhD student at NUIG, presented his work at MaNaPro & ECMNP 2019 (Peniche, Portugal) on the isolation of two new compounds isolated from Halidrys siliquosa, a brown alga collected in Irish waters. For this work, Elliot used freeze dried material present in the Marine Biodiscovery repository. See abtract below.
Meroditerpenoids Isolated from the North-eastern Atlantic Macroalgae Halidrys siliquosa
Elliot Murphy, Kevin Calabro, Perrine Lasserre, Marianela Zanolla, Dagmar B. Stengel, Olivier P. Thomas
Marine Biodiscovery. School of Chemistry and Ryan Institute, National University of Ireland Galway University Road, H91TK33 Galway, Ireland / Botany and Plant Science. School of Natural Sciences and Ryan Institute, National University of Ireland Galway University Road, H91TK33 Galway, Ireland.
Macroalgae have evolved to produce various defence mechanisms including a chemical defence in the form of small metabolites. Halidrys siliquosa, a species of brown algae native to the Atlantic coasts across western Europe, has been shown to contain secondary metabolites exhibiting biological activities in combating various biofilms (Culioli et al).
The aim of our study was to isolate and characterise the structure of the chemical diversity produced by H. siliquosa using a set of analytical techniques. The chemical structures of an outstanding diversity of meroterpenoids present have been first elucidated with 1D and 2D NMR spectroscopic analysis. The question of the absolute configuration was addressed with circular dichroism. A molecular network built on GNPS has also been included in our study to better describe the algae’s metabolome.
Culioli, G., et al., Antifouling activity of meroditerpenoids from the marine brown alga Halidrys siliquosa. Journal of Natural Products, 2008. 71(7): p. 1121-1126.
